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This is so-called reperfusion injury, which can increase the chance of heart failure and can be deadly. However, fresh blood flowing into the damaged heart tissue following successful treatment can trigger inflammation, which happens when white blood cells attack the damaged heart tissues, and cause leaks and clots in small blood vessels in the heart, resulting in further damage. The patient is also given anti-platelet drugs to prevent the artery from clotting again. This is typically treated by a procedure called angioplasty, which reopens the clogged blood vessel and a stent, which prevents the reopened artery from collapsing. First, the clots block the blood flow to the heart and cause a lack of oxygen, resulting in damage to the heart muscles.

Heart attack can cause heart failure and death in two different ways. More than 30% of heart attack survivors suffer from debilitating heart failure, developed from injuries during heart attack. Less than half of the heart attack patients are able to be saved by doctors. alone, there are about 800,000 heart attack cases each year. Heart attack and other disease conditions caused by clots cause more deaths than any other diseases in the world. Our results are published in Science Translational Medicine and show how this drug can effectively treats heart attack in mice. This drug shows promise in treating heart attack and may also be useful for other severe conditions caused by clots, such as stroke and COVID-19 patients with clots and blood vessel leaks.Īs a scientist studying the biology of blood cells and vessels, I am particularly interested in understanding how platelets – a kind of blood cells important in clotting – participate in the formation of clots to stop bleeding or obstructing blood vessels. To address this problem, my colleagues and I have engineered a new anti-platelet drug designed to prevent vessel-blocking blood clots without causing bleeding. Treating clots with available drugs, however, can cause blood vessel leaking and bleeding, which can also be deadly in some circumstances.

They cause heart attack, stroke and are also a major problem in severe cases of COVID-19 patients. Clots obstruct blood vessels and can be deadly.